지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 1 - 15 (15page)
- DOI
- 10.1038/s12276-020-00530-6
이용수
초록· 키워드
오류제보하기
In early pregnancy, the placenta anchors the conceptus and supports embryonic development and survival. This study aimed to investigate the underlying functions of Shh signaling in recurrent miscarriage (RM), a serious disorder of pregnancy. In the present study, Shh and Gli2 were mainly observed in cytotrophoblasts (CTBs), Ptch was mainly observed in syncytiotrophoblasts (STBs), and Smo and Gli3 were expressed in both CTBs and STBs. Shh signaling was significantly impaired in human placenta tissue from recurrent miscarriage patients compared to that of gestational age-matched normal controls. VEGF-A and CD31 protein levels were also significantly decreased in recurrent miscarriage patients. Furthermore, inhibition of Shh signaling impaired the motility of JAR cells by regulating the expression of Gli2 and Gli3. Intriguingly, inhibition of Shh signaling also triggered autophagy and autolysosome accumulation. Additionally, knockdown of BECN1 reversed Gant61-induced motility inhibition. In conclusion, our results showed that dysfunction of Shh signaling activated autophagy to inhibit trophoblast motility, which suggests the Shh pathway and autophagy as potential targets for RM therapy.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
miR-30c regulates proliferation, apoptosis and differentiation via the Shh signaling pathway in P19 cells
Experimental and Molecular Medicine
2016 .01
-
Glioma-Associated Oncogene Homolog1 (Gli1)-Aquaporin1 pathway promotes glioma cell metastasis
BMB Reports
2016 .01
-
Quantitative and qualitative analysis of autophagy flux using imaging
BMB Reports
2020 .01
-
The interplay of microRNAs and transcription factors in autophagy regulation in nonalcoholic fatty liver disease
Experimental and Molecular Medicine
2021 .04
-
Structure biology of selective autophagy receptors
BMB Reports
2016 .01
-
Chemical Inhibition of Autophagy : Examining its Potential to Increase the Specific Productivity of Recombinant CHO Cell Lines
한국생물공학회 학술대회
2016 .04
-
Lentivirus-mediated silencing of the PTC1 and PTC2 genes promotes recovery from spinal cord injury by activating the Hedgehog signaling pathway in a rat model
Experimental and Molecular Medicine
2017 .01
-
Exploiting sweet relief for preeclampsia by targeting autophagy-lysosomal machinery and proteinopathy
Experimental and Molecular Medicine
2024 .05
-
각질세포의 TLR3 활성화에 의한 Autophagy 유전자 발현
KSBB Journal
2022 .12
-
Therapeutic implication of autophagy in neurodegenerative diseases
BMB Reports
2017 .07
-
Sarcopenia targeting with autophagy mechanism by exercise
BMB Reports
2019 .01
-
The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death
Experimental and Molecular Medicine
2021 .04
-
Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300
Experimental and Molecular Medicine
2018 .01
-
Silkworm storage protein 1 inhibits autophagy-mediated apoptosis in mammalian cell
한국생물공학회 학술대회
2018 .10
-
MiR-449a attenuates autophagy of T-cell lymphoma cells by downregulating ATG4B expression
BMB Reports
2020 .01
-
A PDMS-Based Interdigitated Platform for?Trophoblast Invasion Study Under Oxygen Stress Conditions
BioChip Journal
2021 .12
-
Autophagy regulation by acetylation?implications for neurodegenerative diseases
Experimental and Molecular Medicine
2021 .01
-
Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy
BMB Reports
2016 .01
-
miR-24-mediated knockdown of H2AX damages mitochondria and the insulin signaling pathway
Experimental and Molecular Medicine
2017 .01
-
RGS2 promotes estradiol biosynthesis by trophoblasts during human pregnancy
Experimental and Molecular Medicine
2023 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0