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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1994.1
- 수록면
- 839 - 845 (7page)
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초록· 키워드
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One of the major problems of cancer chemotheraphy is the development of drug resistance in tumors, resulting in reduced responsiveness to subsequent treatments. The folate antagonists are being used to treat such diverse illnesses as cancer, leukemia, psoriasis, rheumatoid arthritis, etc. Previous studies have established that resistance to antifolates may occur in mammalian tumor cells by one or more of five mechanisms : (a) an increase in the levels of the target enzyme, generally as a consequence of gene amplification; (b) an alteration in the target enzyme, leading to an enzyme with a decreased binding affinity for the drug; (c) a decrease in the uptake of the drug into the cells; (d) increased extrusion of drugs out of cells; (e) impaired ability to polyglutamylate the parent drug which is capable of being intracellularly metabolized to longer chain length.
목차
Abstract
서론
항엽산제 MTX에 대한 세포의 저항성
결론
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UCI(KEPA) : I410-ECN-0101-2009-511-018097008