지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.12
- 수록면
- 385 - 391 (7page)
이용수
초록· 키워드
오류제보하기
Heterotrimeric GTP binding proteins (G proteins) mediate signals generated by neurotransmitters and hormones. Among G proteins, Go is found in a large quantity in brain and growth cone membranes of neurons. In spite of its abundance in neurons, the role of Go is not fully understood. In our previous study, we identified promyelocytic leukemia zinc finger protein (PLZF) as an interacting partner of alpha subunit of Go (Goα) and confirmed their interaction employing several biochemical assays. To date, it is reported that PLZF functioned as a cell growth suppressor and a transcription repressor. To determine effect of Goα and PLZF interaction on the cellular function of PLZF, we performed luciferase reporter gene assay and BrdU incorporation assay. Co-expression of Goα and PLZF synergistically increased the effect of PLZF alone. These results suggest that Goα may act as cellular activator of PLZF. This novel feature of Go may provide insights into understanding diverse role of Go-coupled receptor as well as its cellular actions.
목차
서론
재료 및 방법
결과
고찰
감사의 글
REFERENCES
참고문헌 (45)
참고문헌 신청
1. [학술지(정기간행물)] - Beaudry, H / 2006 / Involvement of protein kinase C alpha (PKC alpha) in the early action of angiotensin II type 2 (AT2) effects on neurite outgrowth in NG108-15 cells: AT2-receptor inhibits PKC alpha and p21ras activity / Endocrinology 147 : 4263 ~ 4272
2. [학술지(정기간행물)] - Bedecs, K / 1997 / Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase / Biochem J. 325 : 449 ~ 454
3. [학술지(정기간행물)] - Chen, KS / 1994 / Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3 / Biochim Biophys Acta. 1219 : 26 ~ 32
4. [학술지(정기간행물)] - Chen, Z / 1993 / Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia / EMBO J. 12 : 1161 ~ 1167
5. [학술지(정기간행물)] - de Gasparo, M / 2000 / Interna tional union of pharmacology.XXIII(The angiotensin II receptors) / Pharmacol Rev. 52 : 415 ~ 472
2. [학술지(정기간행물)] - Bedecs, K / 1997 / Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase / Biochem J. 325 : 449 ~ 454
3. [학술지(정기간행물)] - Chen, KS / 1994 / Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3 / Biochim Biophys Acta. 1219 : 26 ~ 32
4. [학술지(정기간행물)] - Chen, Z / 1993 / Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia / EMBO J. 12 : 1161 ~ 1167
5. [학술지(정기간행물)] - de Gasparo, M / 2000 / Interna tional union of pharmacology.XXIII(The angiotensin II receptors) / Pharmacol Rev. 52 : 415 ~ 472
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Alpha Subunit of Go Interacts with Promyelocytic Leukemia Zinc Finger Protein
대한의생명과학회지
2004 .12
-
The Alpha Subunit of Go Interacts with Brain Specific High Mobility Group Box Containing Protein
대한의생명과학회지
2006 .12
-
Possible target for G protein antagonist: Identification of specific amino acid residue responsible for the molecular interaction of G$\alpha$ 16 with chemoattractant C5a receptor.
한국응용약물학회 춘계학술발표논문집
2000 .01
-
Protein
대한외과학회 학술대회 초록집
2016 .11
-
Ric-8B Modulates the Function of Alpha Subunit of Go
대한의생명과학회지
2007 .06
-
Molecular interaction of $G{\alpha}16$ subunit G protein with chemoattractant receptors
대한약학회 학술대회
2002 .01
-
Interleukin-8 수용체와 G$_\alpha$ 16 subunit G protein 간의 분자상호 작용에 관한 연구
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2000 .01
-
Uncovering the Protein Function from Protein Interaction Study
한국실험동물학회 학술발표대회 논문집
2004 .06
-
Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein Activation
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
다양한 환경변이원의 분자독성학적 메커니즘 연구에 있어서 항종양 인자 p53의 중요성 고찰
Environmental Analysis Health and Toxicology
2004 .09
-
Differentially Expressed Proteins in Nitric Oxide-Stimulated NIH/3T3 Fibroblasts: Implications for Inhibiting Cancer Development
Yonsei Medical Journal
2015 .01
-
The Catalytic Subunit of Protein Kinase A Interacts with Testis-Brain RNA-Binding Protein (TB-RBP)
대한의생명과학회지
2007 .12
-
Modulation of Rit Activation by the Alpha Subunit of Go
대한의생명과학회지
2009 .12
-
Effects of Hyperbaric Pressure on Cellular Morphology, Proliferation and Protein Expression of Jurkat Cell
Molecular & cellular toxicology
2005 .01
-
Drug Target Discovery Through Protein-Protein Interaction Database
대한약학회 학술대회
2001 .01
-
Mining Proteins Associated with Oral Squamous Cell Carcinoma in Complex Networks
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
Evaluation of Surfactant Cytotoxicity Potential by Neutral Red Uptake Assay , MTT Assay and Cell Protein Assay
한국독성학회지
1994 .06
-
Proteomics Analysis of Gastric Epithelial AGS Cells Infected with Epstein-Barr Virus
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
방사선 방어작용이 있는 인삼 단백분획의 CHO-KI 세포에 대한 세포 독성
약학회지
1988 .01
-
Label-free quantitative proteomic analysis of Panax ginseng leaves upon exposure to heat stress
Journal of Ginseng Research
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-510-017673974