지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Of the Acinetobacter spp., A. baumannii (genospecies 2) is the most clinically significant in terms of hospital-acquired infections worldwide. It is difficult to perform Acinetobacter-related taxonomy using phenotypic characteristics and routine laboratory methods owing to clusters of closely related species. The ability to accurately identify Acinetobacter spp. Is clinically important because antimicrobial susceptibility and clinical relevance differs significantly among the different genospecies. Based on the medical importance of pathogenic Acinetobacter spp., the distribution and characterization of Acinetobacter spp. isolates from 123 clinical samples was determined in the current study using four typically applied bacterial identification methods; partial rpoB gene sequencing, amplified rRNA gene restriction analysis (ARDRA) of the intergenic transcribed spacer (ITS) region of the 16~23S rRNA, the VITEK<SUP>®</SUP> 2 system (an automated microbial identification system) and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS). A. baumannii isolates (74.8%, 92/123) were the most common species, A. nosocomialis (10.6%, 13/123) and A. pittii isolates (7.5%, 9/123) were second and third most common strains of the A. calcoaceticus-A. baumannii (ACB) complex, respectively. A. soli (5.0%, 6/123) was the most common species of the non-ACB complex. RpoB gene sequencing and ARDRA of the ITS region were demonstrated to lead to more accurate species identification than the other methods of analysis used in this study. These results suggest that the use of rpoB genotyping and ARDRA of the ITS region is useful for the species-level identification of Acinetobacter isolates.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (17)
참고문헌 신청
Almasaudi SB / 2018 / Acinetobacter spp. as nosocomial pathogens: Epidemiology and resistance features / Saudi J Biol Sci 25:586~596
Antunes LC / 2014 / Acinetobacter baumannii: evolution of a global pathogen / Pathog Dis 71:292~301
Cisneros JM / 2002 / Nosocomial bacteremia due to Acinetobacter baumannii: epidemiology, clinical features and treatment / Clin Microbiol Infect 8:687~693
Croxatto A / 2012 / Applications of MALDI-TOF mass spectrometry in clinical diagnostic microbiology / FEMS Microbiol Rev 36:380~407
Dingle TC / 2013 / Maldi-tof mass spectrometry for microorganism identification / Clin Lab Med 33:589~609
Antunes LC / 2014 / Acinetobacter baumannii: evolution of a global pathogen / Pathog Dis 71:292~301
Cisneros JM / 2002 / Nosocomial bacteremia due to Acinetobacter baumannii: epidemiology, clinical features and treatment / Clin Microbiol Infect 8:687~693
Croxatto A / 2012 / Applications of MALDI-TOF mass spectrometry in clinical diagnostic microbiology / FEMS Microbiol Rev 36:380~407
Dingle TC / 2013 / Maldi-tof mass spectrometry for microorganism identification / Clin Lab Med 33:589~609
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UCI(KEPA) : I410-ECN-0101-2019-510-000546447