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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 382 - 390 (9page)
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Purpose: The optimal timing of anti-tumor necrosis factor (anti-TNF) initiation in patients with ulcerative colitis (UC) remains unclear. Very little is known about the clinical outcomes after the early versus late initiation of anti-TNF therapy, especially in Asian UC patients. Here we aimed to assess whether earlier anti-TNF treatment initiation results in favorable clinical outcomes in Korean UC patients. Materials and Methods: Using the Korean National Health Insurance claims database, we studied patients who were diagnosed with UC and received anti-TNF therapy for more than 6 months between 2010 and 2016. Using a Cox proportional hazard model, clinical outcomes including colectomy, UC-related emergency room (ER) visits, UC-related hospitalizations, and the need for corticosteroids were compared between early (≤2 years of diagnosis) and late (>2 years of diagnosis) initiators of anti-TNF therapy. Results: Among 17167 UC patients, 698 patients who received anti-TNF therapy for more than 6 months were included (420 infliximab, 242 adalimumab, and 36 golimumab). Of the 698 patients, 299 (42.8%) initiated anti-TNF therapy within 2 years of diagnosis. There were no significant differences in the risk of colectomy [adjusted hazard ratio (aHR), 0.41; 95% confidence interval (CI), 0.04–3.90], ER visits (aHR, 0.98; 95% CI, 0.50–1.92), hospitalization (aHR, 0.76; 95% CI, 0.57–1.01), and corticosteroid use (aHR, 1.04; 95% CI, 0.71–1.50) between early and late initiators of anti-TNF therapy. Conclusion: Patients receiving early anti-TNF therapy had similar clinical outcomes to those of late initiators, suggesting that early anti-TNF therapy initiation offers little benefit in patients with UC.
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참고문헌 (24)
참고문헌 신청
이승훈 / 2018 / Immunological pathogenesis of inflammatory bowel disease / Intestinal research 16(1):26~42
Choon Jin Ooi / 2019 / Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn’s disease in Asia / Intestinal research 17(3):285~310
Rutgeerts P / 2005 / Infliximab for induction and maintenance therapy for ulcerative colitis / N Engl J Med 353:2462~2476
Sandborn WJ / 2012 / Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis / Gastroenterology 142:257~265
Sandborn WJ / 2014 / Subcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis / Gastroenterology 146:85~95
Choon Jin Ooi / 2019 / Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn’s disease in Asia / Intestinal research 17(3):285~310
Rutgeerts P / 2005 / Infliximab for induction and maintenance therapy for ulcerative colitis / N Engl J Med 353:2462~2476
Sandborn WJ / 2012 / Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis / Gastroenterology 142:257~265
Sandborn WJ / 2014 / Subcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis / Gastroenterology 146:85~95
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