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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 214 - 223 (10page)
- DOI
- 10.14348/molcells.2018.2293
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초록· 키워드
오류제보하기
Oligoadenylate synthetase (OAS) protein family is the major interferon (IFN)-stimulated genes responsible for the activation of RNase L pathway upon viral infection. OAS-like (OASL) is also required for inhibition of viral growth in human cells, but the loss of one of its mouse homolog, OASL1, causes a severe defect in termination of type I interferon production. To further investigate the antiviral activity of OASL1, we examined its subcellular localization and regulatory roles in IFN production in the early and late stages of viral infection. We found OASL1, but not OASL2, formed stress granules trapping viral RNAs and promoted efficient RLR signaling in early stages of infection. Stress granule formation was dependent on RNA binding activity of OASL1. But in the late stages of infection, OASL1 interacted with IRF7 transcripts to inhibit translation resulting in down regulation of IFN production. These results implicate that OASL1 plays context dependent functions in the antiviral response for the clearance and resolution of viral infections.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Arimoto, K. / 2008 / Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways / Nat. Cell Biol. 10:1324~1332
Bruns, A.M. / 2015 / LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling / Cytokine 74:198~206
Buchan, J.R. / 2013 / Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function / Cell 153:1461~1474
Chernov, K.G. / 2009 / Role of microtubules in stress granule assembly: microtubule dynamical instability favors the formation of micrometric stress granules in cells / J. Biol. Chem. 284:36569~36580
Choi, B.Y. / 2016 / 2′-5′ oligoadenylate synthetase-like 1 (OASL1) deficiency suppresses central nervous system damage in a murine MOG-induced multiple sclerosis model / Neurosci. Lett. 628:78~84
Bruns, A.M. / 2015 / LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling / Cytokine 74:198~206
Buchan, J.R. / 2013 / Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function / Cell 153:1461~1474
Chernov, K.G. / 2009 / Role of microtubules in stress granule assembly: microtubule dynamical instability favors the formation of micrometric stress granules in cells / J. Biol. Chem. 284:36569~36580
Choi, B.Y. / 2016 / 2′-5′ oligoadenylate synthetase-like 1 (OASL1) deficiency suppresses central nervous system damage in a murine MOG-induced multiple sclerosis model / Neurosci. Lett. 628:78~84
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