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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.2 No.2
발행연도
1997.6
수록면
138 - 143 (6page)

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Crude catechin extracts were prepared using ethyl acetate from Korean Puerariae Radix(PR) and their biological effects on the alcoholic liver damage were investigated in male Sprague-Dawley rats(6 weeks old). Ethanol(5g ethanol/㎏ body weight/day) administration was performed for 8 weeks and after ethanol consuming rats were treated with one or two% catechin extracts of diet for 8 weeks. At the end of experimental period, lipid hydroperoxides in liver were analyzed using a chemiluminescence-high performance liquid chromatography(CL-HPLC) method. Compared with control animals, ethanol consumed rats showed lighter body weights, lower ratios of liver/body weight, higher activities of GOT and GPT, and increased lipid hydroperoxide amount in liver. With one or two% catechin extracts treatment, GOT and GPT activites returned to normal ranges. Lipid hydroperoxide contents in liver of one or two% PR treated rats lowered to 20% or 25% respectively, compared with the levels of those ethanol consumed animals without catechin extracts treatment. Therefore, we concluded that one or two% PR crude catechins treatment could be effective for alcoholic liver damage caused by lipid peroxidation.

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INTRODUCTION

MATERIALS AND METHODS

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