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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 429 - 440 (12page)
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Interferon regulatory factors (IRFs) play a vital role in the innate and adaptive immune system. The Asian swamp eel (Monopterus albus) is one of the most economically important freshwater fishes in China. Immunological data on the species are scare. In the present study, the expression pattern of six types of interferon regulatory factor (IRF) was studied in the Asian swamp eel. Six IRFs except IRF4 were shown to be constitutively expressed in all tissues examined. Their transcription was significantly higher in lymphoid tissues, such as intestine, skin and spleen. Furthermore, IRF1 and IRF5 was also respectively expressed at a high level in the heart and brain. However, the transcript level of IRF4 was low even undetected in most tissues. After polyinosinic- polycytidylic acid (poly I:C) treatment, the transcript levels of IRF1 and IRF4 increased, while those of IRF5 and IRF7 decreased at some time points. However, IRF2 and IRF10 did not respond to the poly I:C challenge. In addition, infection with bacterial pathogen Aermonas hydrophila and an acanthocephalan could upregulate the IRFs’ expression. The results suggested that IRFs are related to the immune response to viral, bacterial and parasitic infection in Asian swamp eel, which will help to clarify the biological function of IRFs in the immune system.
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참고문헌 (56)
참고문헌 신청
Au WC / 1998 / Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon a genes / J Biol Chem 273:29210~29217
Barnes BJ / 2001 / Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes / J Biol Chem 276:23382~23390
Bathige SDNK / 2012 / Interferon regulatory factors 4 and 8 in rock bream, Oplegnathus fasciatus: structural and expressional evidence for their antimicrobial role in teleosts / Fish Shellfish Immunol 33:857~871
Bergan V / 2010 / Regulation and function of interferon regulatory factors of Atlantic salmon / Mol Immunol 47:2005~2014
Brassard P / 1982 / Infection dynamics of Diplostomum spathaceum cercariae and parasite-induced mortality of fish hosts / Parasitology 85:489~493
Barnes BJ / 2001 / Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes / J Biol Chem 276:23382~23390
Bathige SDNK / 2012 / Interferon regulatory factors 4 and 8 in rock bream, Oplegnathus fasciatus: structural and expressional evidence for their antimicrobial role in teleosts / Fish Shellfish Immunol 33:857~871
Bergan V / 2010 / Regulation and function of interferon regulatory factors of Atlantic salmon / Mol Immunol 47:2005~2014
Brassard P / 1982 / Infection dynamics of Diplostomum spathaceum cercariae and parasite-induced mortality of fish hosts / Parasitology 85:489~493
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